Sympathectomy and bone metabolism

[songboy1234]

My opinion that ETS affects bone metabolism has been challenged. I had a disturbing conversation with ETS surgeon Samuel Ahn who told me and the rest of his audience about some of the effects of ETS on bone. Since then my research indicates that the role of the sympathetic nervous system is to inhibit bone resorption. THerefore, one would predict that ETS would lead to increased bone resorption in the denerved area.

This has not been studied in humans, but has been extensively studied in animals. The result? Yes, indeed, sympathectomy increases bone resorption. Please see

http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract

http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract

http://www3.interscience.wiley.com/cgi- ... 1&SRETRY=0

http://www3.interscience.wiley.com/cgi- ... 1/ABSTRACT

I would like anyone else's input on this subject, but please, don't call what I report "bias". If there are any factual errors on my site, it is my policy to correct them immediately. I am truly sorry that what I report is scary. Scary does not make it false, or biased.

Thank You.

Alex Baker

http://www.truthaboutets.com

[Guest]

If osteoblasts can be described as bone forming cells, the osteoclasts can be described as bone destroying cells. Osteoclasts are large, multinucleated cells located on bone surfaces in what are called Howship's lacunae. These lacunae, or resorption pits, are left behind after the breakdown of bone and often present as scalloped surfaces. Because the osteoclasts are derived from a monocyte stem-cell lineage, they are equipped with engulfment strategies similar to circulating macrophages. Osteoclasts mature and/or migrate to discrete bone surfaces. Upon arrival active enzymes, such as acid phosphatase, are secreted against the mineral substrate. This process, called bone resorption, allows stored calcium to be released into systemic circulation and is an important process in regulating calcium balance. As bone formation actively fixes circulating calcium in its mineral form, resorption actively unfixes it thereby increasing circulating calcium levels. These processes occur in tandem at site-specific locations and are known as bone turnover, or remodeling. Osteoblasts and osteoclasts, coupled together via paracrine cell signalling, are referred to as bone remodeling units. The iteration of remodeling events at the cellular level is influential on shaping and sculpting the skeleton both during growth as well as after.






http://en.wikipedia.org/wiki/Bone