Iontophoresis with a 0.05% glycopyrrolate solution better?

[admin]

From the following site:

https://www.mayoclinicproceedings.org/a ... X/fulltext

Iontophoresis

Since 1984, commercial iontophoresis devices have been available for home use. The mechanism of action is unknown. The battery-powered unit delivers a current through tap water–saturated wool pads, separated by a nonconducting barrier placed directly on the treatment site. Patients increase amperage to the maximum output tolerable and treat each site for 30 minutes, up to twice daily. Patients may require daily treatments for up to 2 weeks, which should decrease sweating for several weeks, and repeat treatments as needed. Adverse effects may include pain and small skin burns from the direct current; therefore, alternating current applicators are being developed. Recently, Dolianitis et al have shown iontophoresis with a 0.05% glycopyrrolate solution to be significantly superior to tap water in suppression of palmar hyperhidrosis. Further development and standardization of the technique and equipment for iontophoresis should substantially enhance this treatment alternative.

[pinker]

I've been using Glycopyrrolate for around 10 months or so now. It has been very successful at reducing my hyperhidrosis of the hands and feet.

One 20 minute treatment of the area (10 minutes on each polatity) will usually make my hand/foot 95-100% dry for a week or longer before the sweating of the fingertips and the centre of my palm starts to kick in.

I origionally found using the solution was a compromise because of the short term side effects that came with every treatment. I always got a very dry mouth which lasted around 20 hours at the most, so eating food was difficult with very little saliva. I also got a dry nose and dry eyes and a slight headache.
I strongly advise to at the most, treat one hand and foot one day, and the other limbs on another day, instead of one limb each day. The side effects with treating both hands and feet in one treatment is multiplied to the point it is unbearable.
I've also found the prominence of the side effects increases with current and treatment length. However, longer durations increase the effectivness of the treatment.

However, I have now found that adding glycopyrrolate solution and tap water together in roughly a half and half ratio maintains the same effectivness and gives a significant reduction in side effects. I recieve four 500ml bottles of glycopyrrolate on prescription, I add 250ml to each tray along with approx 250ml of water. This does dilute the solution slightly, but I still feel a very strong current around 8mA and higher, so glycopyrrolate solution must be quite conductive, or the water aids it in some way. I do experience the dry mouth, nose and a little blurred vision which last a few hours; but this is no where near the level it was when using glycopyrrolate on its own.

[blackrob]

pinker or any others - how much does your glycopyrrolate solution cost (USD)? how much do you use during a treatment? what is the concentration of the solution?