Robinul (Glycopyrrolate)

Generic name: Glycopyrrolate

Brand names: Robinul (1mg) and Robinul Forte (2mg)

What are Robinul and Glycopyrrolate?

Glycopyrrolate is a synthetic anticholinergic. An anticholinergic blocks the neurotransmitter acetylcholine, which results in the inhibition of the transmission of parasympathetic nerve impulses. Robinul is the brand name of an oral medication that contains glycopyrrolate.

Uses of Robinul

Robinul is most often used to treat stomach and intestinal ulcers, but the effects are usually temporary. Robinul will decrease the amount of acid in the stomach. A side effect of the drug is that it stops bodily secretions. Consequently, many people use it to treat hyperhidrosis.

Side Effects

Although hyperhidrosis can improve significantly after taking Robinul, there are several unwanted side effects that often arise. The most common are blurred vision, dizziness, drowsiness, dry eyes and dry mouth. Some people also get abdominal bloating and constipation.

Topical Robinul

A number of studies have concluded positive results from topical Robinul creams, gels and lotions. Side effects tend to be less significant then with taking Robinul tablets.

This study from 2002 found 0.5% topical Robinul (i.e., glycopyrrolate) to be effective for craniofacial hyperhidrosis and the patient continued use it at two years treatment follow-up.
A study from South Korea from 2008 found 2% topical Robinul to be very effective at treating primary craniofacial and secondary gustatory hyperhidrosis.
Yet another one on 2% topical Robinul for facial sweating from South Korea (2015).

Other Items of Interest

Check out the Robinul Forum for patient reviews, recommendations and testimonials regarding Robinul and Robinul Forte.